

| Rank | Player | Tackles |
|---|---|---|
| T-378 | Tyleik WilliamsDetroit Lions · DT | 16 |
| T-378 | Vita VeaTampa Bay Buccaneers · DT | 16 |
| T-397 | Byron YoungPhiladelphia Eagles · DT | 15 |
| T-397 | Chris McClellanGreen Bay Packers · DT | 15 |
| T-397 | Gracen HaltonSan Francisco 49ers · DT | 15 |
| T-397 | Jerry TilleryIndianapolis Colts · DT | 15 |
| T-397 | Karl BrooksGreen Bay Packers · DT | 15 |
| T-397 | Maason SmithAtlanta Falcons · DT | 15 |
| T-397 | Poona FordLos Angeles Rams · DT | 15 |
| T-397 | Shelby HarrisNew York Giants · DT | 15 |
| T-397 | Teair TartLos Angeles Chargers · DT | 15 |
| T-397 | Tonka HemingwayLas Vegas Raiders · DT | 15 |
| T-426 | Alim McNeillDetroit Lions · DT | 14 |
| T-426 | Daron PayneWashington Commanders · DT | 14 |
| T-426 | Davon GodchauxNew Orleans Saints · DT | 14 |
| T-426 | Levi Drake RodriguezMinnesota Vikings · DT | 14 |
| T-426 | Vernon BroughtonNew Orleans Saints · DT | 14 |
| T-426 | Walter Nolen IIIArizona Cardinals · DT | 14 |
| T-426 | Zeek BiggersMiami Dolphins · DT | 14 |
| T-453 | B.J. HillCincinnati Bengals · DT | 13 |
| T-453 | Brandon DorlusAtlanta Falcons · DT | 13 |
| T-453 | Chris JonesKansas City Chiefs · DT | 13 |
| T-453 | Folorunso FatukasiLas Vegas Raiders · DT | 13 |
| T-453 | Jamaree CaldwellLos Angeles Chargers · DT | 13 |
| T-453 | Javon KinlawWashington Commanders · DT | 13 |
| T-453 | Khyiris TongaKansas City Chiefs · DT | 13 |
| T-453 | Osa OdighizuwaSan Francisco 49ers · DT | 13 |
| T-453 | Peter WoodsKansas City Chiefs · DT | 13 |
| T-453 | Shy TuttleWashington Commanders · DT | 13 |
| T-453 | Solomon ThomasTennessee Titans · DT | 13 |
| T-453 | Thomas Booker IVLas Vegas Raiders · DT | 13 |
| T-480 | Aaron DonaldLos Angeles Rams · DT | 12 |
| T-480 | Arik ArmsteadJacksonville Jaguars · DT | 12 |
| T-480 | Caleb BanksMinnesota Vikings · DT | 12 |
| T-480 | Derrick HarmonPittsburgh Steelers · DT | 12 |
| T-480 | Nathan ShepherdNew Orleans Saints · DT | 12 |
| T-480 | Ruke OrhorhoroJacksonville Jaguars · DT | 12 |
| T-508 | Greg GainesBuffalo Bills · DT | 11 |
| T-508 | Jordan ElliottTennessee Titans · DT | 11 |
| T-508 | Nick BarrettLos Angeles Chargers · DT | 11 |
| T-508 | Skyler Gill-HowardDetroit Lions · DT | 11 |
| T-508 | T.J. Slaton Jr.Cincinnati Bengals · DT | 11 |
| T-508 | Tim SettleWashington Commanders · DT | 11 |
| T-533 | Dalvin TomlinsonLos Angeles Chargers · DT | 10 |
| T-533 | John JenkinsBaltimore Ravens · DT | 10 |
| T-533 | Khristian BoydNew Orleans Saints · DT | 10 |
| T-533 | Sam KamaraCleveland Browns · DT | 10 |
| T-533 | Sebastian Joseph-DayPittsburgh Steelers · DT | 10 |
| T-568 | Calijah KanceyTampa Bay Buccaneers · DT | 9 |
| T-568 | Ed OliverBuffalo Bills · DT | 9 |
Regular season, from ESPN, refreshed hourly. Every stat