

| Rank | Player | Tackles |
|---|---|---|
| T-397 | Michael Carter IIPhiladelphia Eagles · CB | 15 |
| T-397 | Nolan Smith Jr.Philadelphia Eagles · LB | 15 |
| T-397 | Poona FordLos Angeles Rams · DT | 15 |
| T-397 | Rodney Thomas IISeattle Seahawks · S | 15 |
| T-397 | Shaun DolacLos Angeles Rams · LB | 15 |
| T-397 | Shelby HarrisNew York Giants · DT | 15 |
| T-397 | Tyree WilsonNew Orleans Saints · DE | 15 |
| T-397 | Uchenna NwosuSeattle Seahawks · LB | 15 |
| T-426 | Alim McNeillDetroit Lions · DT | 14 |
| T-426 | Chase YoungNew Orleans Saints · DE | 14 |
| T-426 | Daron PayneWashington Commanders · DT | 14 |
| T-426 | Davon GodchauxNew Orleans Saints · DT | 14 |
| T-426 | DJ WonnumDetroit Lions · LB | 14 |
| T-426 | Ifeatu MelifonwuTampa Bay Buccaneers · S | 14 |
| T-426 | Ivan Pace Jr.Minnesota Vikings · LB | 14 |
| T-426 | Kenny Moore IIPhiladelphia Eagles · CB | 14 |
| T-426 | Levi Drake RodriguezMinnesota Vikings · DT | 14 |
| T-426 | Marcus EppsPhiladelphia Eagles · S | 14 |
| T-426 | Micah McFaddenNew York Giants · LB | 14 |
| T-426 | Vernon BroughtonNew Orleans Saints · DT | 14 |
| T-426 | Walter Nolen IIIArizona Cardinals · DT | 14 |
| T-426 | Wesley BaileyLos Angeles Rams · LB | 14 |
| T-453 | A.J. Terrell Jr.Atlanta Falcons · CB | 13 |
| T-453 | Brandon DorlusAtlanta Falcons · DT | 13 |
| T-453 | Cameron JordanNew Orleans Saints · DE | 13 |
| T-453 | Dadrion Taylor-DemersonArizona Cardinals · S | 13 |
| T-453 | Daniel HardyChicago Bears · DE | 13 |
| T-453 | Grady JarrettChicago Bears · DE | 13 |
| T-453 | Javon KinlawWashington Commanders · DT | 13 |
| T-453 | Keion WhiteSan Francisco 49ers · DE | 13 |
| T-453 | Kyle Van NoyMinnesota Vikings · LB | 13 |
| T-453 | Malachi LawrenceDallas Cowboys · LB | 13 |
| T-453 | Osa OdighizuwaSan Francisco 49ers · DT | 13 |
| T-453 | Shy TuttleWashington Commanders · DT | 13 |
| T-480 | Aaron DonaldLos Angeles Rams · DT | 12 |
| T-480 | Alijah ClarkDallas Cowboys · S | 12 |
| T-480 | Ameer SpeedDallas Cowboys · CB | 12 |
| T-480 | Avieon TerrellAtlanta Falcons · CB | 12 |
| T-480 | Baron BrowningArizona Cardinals · LB | 12 |
| T-480 | Brevyn Spann-FordDallas Cowboys · TE | 12 |
| T-480 | Caleb BanksMinnesota Vikings · DT | 12 |
| T-480 | Chauncey GolstonNew York Giants · DE | 12 |
| T-480 | Elijah RobertsTampa Bay Buccaneers · DE | 12 |
| T-480 | Hunter LuepkeDallas Cowboys · FB | 12 |
| T-480 | Kain MedranoWashington Commanders · LB | 12 |
| T-480 | Kalen KingArizona Cardinals · CB | 12 |
| T-480 | Khalil DorseyDetroit Lions · CB | 12 |
| T-480 | L.J. CollierArizona Cardinals · DE | 12 |
| T-480 | Nathan ShepherdNew Orleans Saints · DT | 12 |
| T-480 | Noah SewellChicago Bears · LB | 12 |
Regular season, from ESPN, refreshed hourly. Every stat