

| Rank | Player | Rush Yds |
|---|---|---|
| 3 | Kenneth Walker IIIKansas City Chiefs · RB | 770 |
| 5 | James Cook IIIBuffalo Bills · RB | 707 |
| 6 | Jaylen WarrenPittsburgh Steelers · RB | 704 |
| 7 | Derrick HenryBaltimore Ravens · RB | 632 |
| 8 | Jonathan TaylorIndianapolis Colts · RB | 610 |
| 9 | Tony PollardTennessee Titans · RB | 595 |
| 10 | Braelon AllenNew York Jets · RB | 565 |
| 15 | Bhayshul TutenJacksonville Jaguars · RB | 492 |
| 18 | Ollie Gordon IIMiami Dolphins · RB | 408 |
| 22 | Rhamondre StevensonNew England Patriots · RB | 367 |
| 23 | Quinshon JudkinsCleveland Browns · RB | 342 |
| 24 | Chase BrownCincinnati Bengals · RB | 340 |
| 25 | Ashton JeantyLas Vegas Raiders · RB | 337 |
| 28 | Omarion HamptonLos Angeles Chargers · RB | 309 |
| 29 | J.K. DobbinsDenver Broncos · RB | 306 |
| 31 | Mike Washington Jr.Las Vegas Raiders · RB | 278 |
| 33 | Woody MarksHouston Texans · RB | 271 |
| 43 | Chris Rodriguez Jr.Jacksonville Jaguars · RB | 209 |
| 44 | TreVeyon HendersonNew England Patriots · RB | 203 |
| 46 | Corey KinerNew England Patriots · RB | 189 |
| 48 | Rico DowdlePittsburgh Steelers · RB | 174 |
| T-51 | Breece HallNew York Jets · RB | 163 |
| T-51 | Seth McGowanIndianapolis Colts · RB | 163 |
| 55 | Justice HillBaltimore Ravens · RB | 155 |
| 59 | Keaton MitchellLos Angeles Chargers · RB | 145 |
| 61 | David MontgomeryHouston Texans · RB | 138 |
| 62 | Samaje PerineCincinnati Bengals · RB | 136 |
| 63 | Jonah ColemanDenver Broncos · RB | 134 |
| 64 | Kimani VidalLos Angeles Chargers · RB | 132 |
| 67 | De'Von AchaneMiami Dolphins · RB | 127 |
| T-82 | RJ HarveyDenver Broncos · RB | 87 |
| T-92 | Emmett JohnsonKansas City Chiefs · RB | 77 |
| T-97 | Jaleel McLaughlinCleveland Browns · RB | 72 |
| 102 | Tyjae SpearsTennessee Titans · RB | 66 |
| 103 | Ameer AbdullahJacksonville Jaguars · RB | 58 |
| 107 | Dylan SampsonCleveland Browns · RB | 52 |
| 112 | Isaiah DavisNew York Jets · RB | 44 |
| T-113 | DJ GiddensIndianapolis Colts · RB | 43 |
| T-113 | Jawhar JordanHouston Texans · RB | 43 |
| T-113 | Raheim SandersCleveland Browns · RB | 43 |
| 117 | Ray DavisBuffalo Bills · RB | 42 |
| T-118 | Jaylen WrightMiami Dolphins · RB | 41 |
| T-118 | Kaytron AllenMiami Dolphins · RB | 41 |
| T-140 | Rasheen AliBaltimore Ravens · RB | 24 |
| 146 | Tyler BadieDenver Broncos · RB | 22 |
| T-154 | Audric EstimeCleveland Browns · RB | 19 |
| T-164 | Travis HomerPittsburgh Steelers · RB | 15 |
| T-172 | Nicholas SingletonTennessee Titans · RB | 12 |
| T-180 | Ty JohnsonBuffalo Bills · RB | 10 |
| T-185 | Dylan LaubeLas Vegas Raiders · RB | 9 |
Regular season, from ESPN, refreshed hourly. Every stat