

| Rank | Player | Tackles |
|---|---|---|
| T-73 | Jeffery SimmonsChicago Bears · DT | 44 |
| T-166 | Quinnen WilliamsDallas Cowboys · DT | 29 |
| T-178 | Jordan DavisPhiladelphia Eagles · DT | 28 |
| T-192 | Byron Murphy IISeattle Seahawks · DT | 27 |
| T-211 | Leonard WilliamsSeattle Seahawks · DT | 25 |
| T-227 | Otito OgbonniaDallas Cowboys · DT | 24 |
| T-243 | Jalen CarterPhiladelphia Eagles · DT | 23 |
| T-243 | Roy LopezArizona Cardinals · DT | 23 |
| T-261 | A'Shawn RobinsonTampa Bay Buccaneers · DT | 22 |
| T-261 | Dante StillsArizona Cardinals · DT | 22 |
| T-261 | Gervon Dexter Sr.Atlanta Falcons · DT | 22 |
| T-261 | Jalen RedmondMinnesota Vikings · DT | 22 |
| T-279 | Derrick BrownCarolina Panthers · DT | 21 |
| T-279 | DJ ReaderNew York Giants · DT | 21 |
| T-279 | Moro OjomoPhiladelphia Eagles · DT | 21 |
| T-298 | Devonte WyattGreen Bay Packers · DT | 20 |
| T-315 | Aaron HallCarolina Panthers · DT | 19 |
| T-315 | Kenny ClarkDallas Cowboys · DT | 19 |
| T-337 | James LynchChicago Bears · DT | 18 |
| T-337 | Jarran ReedSeattle Seahawks · DT | 18 |
| T-378 | Colby WoodenNew Orleans Saints · DT | 16 |
| T-378 | Lee HunterCarolina Panthers · DT | 16 |
| T-378 | Tyleik WilliamsDetroit Lions · DT | 16 |
| T-378 | Vita VeaTampa Bay Buccaneers · DT | 16 |
| T-397 | Byron YoungPhiladelphia Eagles · DT | 15 |
| T-397 | Chris McClellanGreen Bay Packers · DT | 15 |
| T-397 | Gracen HaltonSan Francisco 49ers · DT | 15 |
| T-397 | Karl BrooksGreen Bay Packers · DT | 15 |
| T-397 | Maason SmithAtlanta Falcons · DT | 15 |
| T-397 | Poona FordLos Angeles Rams · DT | 15 |
| T-397 | Shelby HarrisNew York Giants · DT | 15 |
| T-426 | Alim McNeillDetroit Lions · DT | 14 |
| T-426 | Daron PayneWashington Commanders · DT | 14 |
| T-426 | Davon GodchauxNew Orleans Saints · DT | 14 |
| T-426 | Levi Drake RodriguezMinnesota Vikings · DT | 14 |
| T-426 | Vernon BroughtonNew Orleans Saints · DT | 14 |
| T-426 | Walter Nolen IIIArizona Cardinals · DT | 14 |
| T-453 | Brandon DorlusAtlanta Falcons · DT | 13 |
| T-453 | Javon KinlawWashington Commanders · DT | 13 |
| T-453 | Osa OdighizuwaSan Francisco 49ers · DT | 13 |
| T-453 | Shy TuttleWashington Commanders · DT | 13 |
| T-480 | Aaron DonaldLos Angeles Rams · DT | 12 |
| T-480 | Caleb BanksMinnesota Vikings · DT | 12 |
| T-480 | Nathan ShepherdNew Orleans Saints · DT | 12 |
| T-508 | Skyler Gill-HowardDetroit Lions · DT | 11 |
| T-508 | Tim SettleWashington Commanders · DT | 11 |
| T-533 | Khristian BoydNew Orleans Saints · DT | 10 |
| T-568 | Calijah KanceyTampa Bay Buccaneers · DT | 9 |
| T-568 | James Thompson Jr.San Francisco 49ers · DT | 9 |
| T-568 | Kentavius StreetChicago Bears · DT | 9 |
Regular season, from ESPN, refreshed hourly. Every stat