| Pos | 1st | 2nd | 3rd | 4th | 5th | 6th |
|---|---|---|---|---|---|---|
| LDE | 56Keion WhiteTrade · NE | 98Mykel Williams'25 Rd 1 | 63Viliami Fehoko Jr.PSFA '26 | 59Ogbo OkoronkwoPSFA · PHI | 91Sam OkuayinonuIR | 59Mikail KamaraIR |
| LDT | 92Osa OdighizuwaTrade · DAL | 55Sebastian ValdezUDFA '25 | 65McKinnley JacksonPSFA '26 | 90C.J. WestIR | ||
| RDT | 99DeForest BucknerTrade · IND | 93Gracen Halton'26 Rd 4 | 96James Thompson Jr.UDFA '26 | 95Alfred CollinsIR | ||
| RDE | 97Nick Bosa'19 Rd 1 | 94Romello Height'26 Rd 3 | 47Khalid Kareem | —Robert Beal Jr.PSFA '26 | 50Andrew Farmer IIIR | |
| WLB | 57Dre GreenlawCap cut · DEN | 53Jaden Dugger'26 Rd 5 | 48Tatum Bethune'24 Rd 7 | 41Jalen GrahamPS | ||
| MLB | 54Fred Warner'18 Rd 3 | 49Garret WallowWaivers · DEN | 51Luke GiffordFA · TEN | 45Nick MartinIR | ||
| LCB | 0Renardo Green'24 Rd 2 | 40Brandon CodringtonPSFA '26 | 22Nate HobbsIR | |||
| SS | 36Marques Sigle'25 Rd 5 | 6Malik Mustapha'24 Rd 4 | 38Jalen StromanPSUDFA '26 | |||
| FS | 27Ji'Ayir Brown'23 Rd 3 | 24Ashtyn DavisFA · MIA | 29Darrick ForrestIR | |||
| RCB | 2Deommodore Lenoir'21 Rd 5 | 28Ephesians Prysock'26 Rd 4 | ||||
| NB | 20Upton Stout'25 Rd 3 | 33Siran NealFA · MIA |
| Pos | 1st | 2nd | 3rd |
|---|---|---|---|
| PT | 15Corliss WaitmanFA · PIT | ||
| PK | 18Eddy PineiroFA · CAR | ||
| LS | 46Jon WeeksFA · HOU | ||
| H | 15Corliss WaitmanFA · PIT | ||
| KO | 18Eddy PineiroFA · CAR | ||
| PR | 4Jacob Cowing'24 Rd 4 | 17Jordan Watkins'25 Rd 4 | |
| KR | 19Deebo Samuel Sr.FA · WAS | 4Jacob Cowing'24 Rd 4 | 17Jordan Watkins'25 Rd 4 |
Depth chart updated Nov 3 · Ourlads · PS = practice squad · IR = injured reserve · LEFT = LEFT · PUP = physically unable to perform
| # | Player | Pos | Age | Ht | Wt | Exp | College | |
|---|---|---|---|---|---|---|---|---|
| 13 |  Brock PurdyStarter | QB | 26 | 6'1" | 220 | 5 | Iowa State | |
| 10 |  Mac Jones | QB | 28 | 6'3" | 220 | 6 | Alabama | |
| 14 |  Kurtis Rourke | QB | 26 | 6'4" | 220 | 1 | Indiana | |
| 23 |  Christian McCaffreyStarterQuestionable | RB | 30 | 5'11" | 210 | 10 | Stanford | |
| 26 |  Kaelon Black | RB | 25 | 5'9" | 208 | R | Indiana | |
| 29 |  Jordan James | RB | 22 | 5'9" | 208 | 2 | Oregon | |
| 44 |  Kyle Juszczyk | FB | 35 | 6'2" | 235 | 14 | Harvard | |
| 5 |  Mike EvansStarterQuestionable | WR | 33 | 6'5" | 231 | 13 | Texas A&M | |
| 17 |  Jordan WatkinsStarter | WR | 24 | 5'11" | 196 | 2 | Ole Miss | |
| 19 |  Deebo Samuel Sr.StarterQuestionable | WR | 30 | 6'0" | 215 | 8 | South Carolina | |
| 3 |  Christian KirkQuestionable | WR | 29 | 5'11" | 200 | 9 | Texas A&M | |
| 4 |  Jacob Cowing | WR | 25 | 5'9" | 171 | 3 | Arizona | |
| 11 |  Brandon AiyukOut | WR | 28 | 6'0" | 200 | 6 | Arizona State | |
| 84 |  Brandin Cooks | WR | 33 | 5'10" | 189 | 13 | Oregon State | |
| 85 |  George KittleStarter | TE | 33 | 6'4" | 250 | 10 | Iowa | |
| 9 |  Brayden Willis | TE | 26 | 6'4" | 240 | 4 | Oklahoma | |
| 89 |  Jack Stoll | TE | 28 | 6'4" | 245 | 6 | Nebraska | |
| 89 |  Luke Farrell | TE | 29 | 6'5" | 250 | 6 | Ohio State | |
| 68 |  Colton McKivitzStarter | OT | 30 | 6'6" | 301 | 7 | West Virginia | |
| 71 |  Trent WilliamsStarter | OT | 38 | 6'5" | 320 | 17 | Oklahoma | |
| 69 |  Enrique Cruz Jr. | OT | 23 | 6'5" | 313 | R | Kansas | |
| 74 |  Carver Willis | OT | 24 | 6'5" | 303 | R | Washington | |
| 76 |  Vederian Lowe | OT | 27 | 6'6" | 320 | 5 | Illinois | |
| 75 |  Connor ColbyStarter | G | 23 | 6'5" | 309 | 2 | Iowa | |
| 77 |  Dominick PuniStarter | G | 26 | 6'5" | 313 | 3 | Kansas | |
| 58 |  Jarrett Patterson | G | 27 | 6'4" | 310 | 4 | Notre Dame | |
| 64 |  Jake BrendelStarter | C | 34 | 6'4" | 299 | 9 | UCLA |
| # | Player | Pos | Age | Ht | Wt | Exp | College | |
|---|---|---|---|---|---|---|---|---|
| 56 |  Keion WhiteStarter | DE | 27 | 6'5" | 290 | 4 | Georgia Tech | |
| 97 |  Nick BosaStarterQuestionable | DE | 29 | 6'4" | 266 | 8 | Ohio State | |
| 47 |  Khalid Kareem | DE | 28 | 6'4" | 268 | 4 | Notre Dame | |
| 94 |  Romello Height | DE | 25 | 6'2" | 239 | R | Texas Tech | |
| 98 |  Mykel Williams | DE | 22 | 6'5" | 267 | 2 | Georgia | |
| 92 |  Osa OdighizuwaStarter | DT | 28 | 6'2" | 294 | 6 | UCLA | |
| — |  DeForest BucknerStarter | DT | 32 | 6'7" | 295 | 11 | Oregon | |
| 55 |  Sebastian Valdez | DT | 24 | 6'3" | 301 | 1 | Washington | |
| 93 |  Gracen Halton | DT | 22 | 6'2" | 293 | R | Oklahoma | |
| 96 |  James Thompson Jr. | DT | 24 | 6'6" | 308 | R | Illinois | |
| 54 |  Fred WarnerStarter | LB | 29 | 6'3" | 230 | 9 | BYU | |
| 57 |  Dre GreenlawStarter | LB | 29 | 6'0" | 230 | 8 | Arkansas | |
| 41 |  Jalen Graham | LB | 25 | 6'3" | 220 | 3 | Purdue | |
| 48 |  Tatum Bethune | LB | 25 | 6'1" | 230 | 3 | Florida State | |
| 49 |  Garret WallowQuestionable | LB | 27 | 6'2" | 230 | 6 | TCU | |
| 51 |  Luke GiffordQuestionable | LB | 31 | 6'3" | 243 | 8 | Nebraska | |
| 53 |  Jaden Dugger | LB | 22 | 6'4" | 240 | R | Louisiana | |
| 59 |  Ogbo Okoronkwo | LB | 31 | 6'2" | 253 | 9 | Oklahoma | |
| 0 |  Renardo GreenStarter | CB | 25 | 6'0" | 186 | 3 | Florida State | |
| 2 |  Deommodore LenoirStarter | CB | 27 | 5'10" | 200 | 6 | Oregon | |
| 20 |  Upton StoutStarterQuestionable | CB | 24 | 5'9" | 181 | 2 | Western Kentucky | |
| 28 |  Ephesians Prysock | CB | 23 | 6'3" | 196 | R | Washington | |
| 27 |  Ji'Ayir BrownStarter | S | 26 | 5'11" | 202 | 4 | Penn State | |
| 36 |  Marques SigleStarterQuestionable | S | 24 | 5'11" | 199 | 2 | Kansas State | |
| 6 |  Malik Mustapha | S | 24 | 5'10" | 206 | 3 | Wake Forest | |
| 24 |  Ashtyn Davis | S | 30 | 6'1" | 205 | 7 | California | |
| 33 |  Siran NealQuestionable | S | 32 | 6'0" | 206 | 9 | Jacksonville State |
| # | Player | Pos | Age | Ht | Wt | Exp | College | |
|---|---|---|---|---|---|---|---|---|
| 18 |  Eddy PineiroStarter | PK | 31 | 5'11" | 190 | 9 | Florida | |
| 15 |  Corliss WaitmanStarter | P | 31 | 6'2" | 210 | 4 | South Alabama | |
| 46 |  Jon WeeksStarter | LS | 40 | 5'10" | 242 | 17 | Baylor |
| # | Player | Pos | Age | Ht | Wt | Exp | College | |
|---|---|---|---|---|---|---|---|---|
| 78 |  Brett TothQuestionable | C | 30 | 6'6" | 304 | 7 | Army |
| # | Player | Pos | Age | Ht | Wt | Exp | College | |
|---|---|---|---|---|---|---|---|---|
| — |  Vincent Anthony Jr. | DE | 22 | 6'6" | 260 | R | Duke |
