| Rank | Player | Sacks |
|---|---|---|
| T-12 | Dexter Lawrence IICincinnati Bengals · DT | 5.0 |
| T-23 | Adetomiwa AdebaworeIndianapolis Colts · DT | 4.0 |
| T-23 | DeForest BucknerIndianapolis Colts · DT | 4.0 |
| T-23 | Mason GrahamCleveland Browns · DT | 4.0 |
| T-34 | Christian BarmoreNew England Patriots · DT | 3.5 |
| T-34 | Malcolm RoachDenver Broncos · DT | 3.5 |
| T-34 | Maliek CollinsCleveland Browns · DT | 3.5 |
| T-45 | Jonathan AllenCincinnati Bengals · DT | 3.0 |
| T-70 | Cameron HeywardPittsburgh Steelers · DT | 2.5 |
| T-78 | Jowon BriggsNew York Jets · DT | 2.0 |
| T-78 | Kris Jenkins Jr.Cincinnati Bengals · DT | 2.0 |
| T-78 | Leonard Taylor IIINew England Patriots · DT | 2.0 |
| T-78 | Sheldon RankinsHouston Texans · DT | 2.0 |
| T-78 | Zach SielerMiami Dolphins · DT | 2.0 |
| T-114 | Arik ArmsteadJacksonville Jaguars · DT | 1.5 |
| T-114 | Cory DurdenNew England Patriots · DT | 1.5 |
| T-114 | Derrick HarmonPittsburgh Steelers · DT | 1.5 |
| T-135 | D.J. JonesDenver Broncos · DT | 1.0 |
| T-135 | Darrell Jackson Jr.New York Jets · DT | 1.0 |
| T-135 | Deone WalkerBuffalo Bills · DT | 1.0 |
| T-135 | DeWayne CarterBuffalo Bills · DT | 1.0 |
| T-135 | Jerry TilleryIndianapolis Colts · DT | 1.0 |
| T-135 | Joshua FarmerNew England Patriots · DT | 1.0 |
| T-135 | Kevin Jobity Jr.Pittsburgh Steelers · DT | 1.0 |
| T-135 | Mario Edwards Jr.Houston Texans · DT | 1.0 |
| T-135 | Mike Hall Jr.Cleveland Browns · DT | 1.0 |
| T-135 | Milton WilliamsNew England Patriots · DT | 1.0 |
| T-135 | Nnamdi MadubuikeBaltimore Ravens · DT | 1.0 |
| T-135 | Ruke OrhorhoroJacksonville Jaguars · DT | 1.0 |
| T-135 | Sam KamaraCleveland Browns · DT | 1.0 |
| T-135 | Tim Keenan IIILas Vegas Raiders · DT | 1.0 |
| T-135 | Tonka HemingwayLas Vegas Raiders · DT | 1.0 |
| T-261 | Adam ButlerLas Vegas Raiders · DT | 0.5 |
| T-261 | Chris JonesKansas City Chiefs · DT | 0.5 |
| T-261 | Dalvin TomlinsonLos Angeles Chargers · DT | 0.5 |
| T-261 | DaVon HamiltonJacksonville Jaguars · DT | 0.5 |
| T-261 | Ed OliverBuffalo Bills · DT | 0.5 |
| T-261 | Folorunso FatukasiLas Vegas Raiders · DT | 0.5 |
| T-261 | Grover StewartIndianapolis Colts · DT | 0.5 |
| T-261 | Jaden CrumedyHouston Texans · DT | 0.5 |
| T-261 | Jonah LauluLas Vegas Raiders · DT | 0.5 |
| T-261 | Justin EboigbeLos Angeles Chargers · DT | 0.5 |
| T-261 | Keeanu BentonPittsburgh Steelers · DT | 0.5 |
| T-261 | Nick BarrettLos Angeles Chargers · DT | 0.5 |
| T-261 | Peter WoodsKansas City Chiefs · DT | 0.5 |
Regular season, from ESPN, refreshed hourly. Every stat